Amlodipine: Calcium Channel Blocker for Blood Pressure

Amlodipine is a medication classified as a calcium channel blocker, commonly used to treat hypertension (high blood pressure) and angina (chest pain). It belongs to the dihydropyridine class of calcium channel blockers, which primarily act on the smooth muscle cells of arteries and arterioles.

Mechanism of Action

Calcium Channel Blockade

Amlodipine works by inhibiting the influx of calcium ions into vascular Semaglutide oral smooth muscle cells, leading to vasodilation and subsequent reduction in blood pressure. By blocking calcium channels, it relaxes blood vessels, making it easier for the heart to pump blood.


The vasodilatory effect of amlodipine primarily targets peripheral arterioles, resulting in decreased peripheral resistance and improved blood flow to various organs, including the heart and kidneys.

Indications for Use


Amlodipine is FDA-approved for the treatment of hypertension, either alone or in combination with other antihypertensive agents. It is often prescribed as first-line therapy due to its efficacy and favorable side effect profile.


In addition to hypertension, amlodipine is indicated for the management of chronic stable angina. It helps reduce the frequency of angina episodes and improves exercise tolerance by dilating coronary arteries, thereby increasing myocardial oxygen delivery.

Other Off-Label Uses

Although not FDA-approved for these indications, amlodipine may be used off-label for conditions such as Raynaud’s phenomenon, migraine prophylaxis, and certain types of heart failure.

Dosage and Administration

Initial Dosing

The typical starting dose of amlodipine for hypertension is 5 mg once daily, which may be titrated up to 10 mg daily based on individual patient response. For angina, the recommended starting dose is 5 mg once daily, with the possibility of increasing to 10 mg daily if needed.


Dose adjustments should be made cautiously, with close monitoring of blood pressure and heart rate. Amlodipine can be taken with or without food, but consistency in administration is essential for optimal therapeutic outcomes.

Special Populations

Dose adjustments may be necessary in patients with hepatic impairment or severe renal dysfunction. Elderly patients may also require lower initial doses due to age-related changes in drug metabolism and clearance.

Side Effects and Adverse Reactions

Common Side Effects

The most common side effects of amlodipine include peripheral edema, headache, dizziness, and flushing. These side effects are usually mild to moderate in severity and often resolve with continued therapy.

Serious Adverse Reactions

Rare but serious adverse reactions associated with amlodipine include hypotension, bradycardia, and exacerbation of heart failure. Patients should be monitored for signs of fluid retention, especially in those with pre-existing cardiac conditions.

Drug Interactions

Amlodipine has the potential for drug interactions with other medications that affect blood pressure or heart rate. Concomitant use with strong CYP3A4 inhibitors or inducers should be avoided, as it may lead to significant changes in amlodipine plasma concentrations.